Progress and limits of PrP gene selection policy
نویسندگان
چکیده
منابع مشابه
Progress and limits of PrP gene selection policy.
Classical scrapie has proved to be a notoriously difficult disease to control due to a poor understanding of its natural history. The recognition of disease risk linkage to PrP genotype has offered the prospect of a disease control strategy, viz. genotyping and selective breeding, novel to veterinary medicine when first considered in the 1990s. The UK Spongiform Encephalopathy Advisory Committe...
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15 صفحه اولGene flow and the limits to natural selection
cefe.cnrs-mop.fr Under natural selection, individuals tend to adapt to their local environmental conditions, resulting in a pattern of LOCAL ADAPTATION (see Glossary). Local adaptation can occur if the direction of selection changes for an allele among habitats (antagonistic environmental effect), but it might also occur if the intensity of selection at several loci that are maintained as polym...
متن کاملAre Sinc and the PrP gene congruent? Evidence from PrP gene analysis in Sinc congenic mice.
Congenic mouse strains VM/Dk and VM-Sincs7/Dk differ at the Sinc gene, which controls the incubation period of scrapie in mice; VM/Dk mice are Sincp7p7 and VM-Sincs7/Dk mice are Sincs7s7. Restriction fragment length polymorphism and DNA sequencing analysis demonstrated that the PrP genes also differ in these strains, confirming the close genetic linkage of Sinc and PrP. Using the restriction en...
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Following the two "mad cow" crises of 1996 and 2000, there was an urgent need for rapid and sensitive diagnostic methods to identify animals infected with the bovine spongiform encephalopathy (BSE) agent. This stimulated research in the field of prion diagnosis and led to the establishment of numerous so-called "rapid tests" which have been in use in Europe since 2001 for monitoring at-risk pop...
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ژورنال
عنوان ژورنال: Veterinary Research
سال: 2008
ISSN: 0928-4249,1297-9716
DOI: 10.1051/vetres:2007064